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http://www.authorstream.com/Presentation/lukarb-3582344-transdermal-permeation-enhancer/ SEMINAR ON TRANSDERMAL PERMEATION ENHANCER: SEMINAR ON TRANSDERMAL PERMEATION ENHANCER Presented by : Pathan Lukmankhan S M.Pharm Semester I Pharmaceutics 1 Slide2: OBJECTIVE ABSORPTION THROUGH SKIN BARRIERS FACTORS PERMEATION ENHANCEMENT REFERENCES Content CONCLUSION INTRODUCTION 2 Slide3: Objectives 3 Slide4: TDDS DEFINITION : Transdermal delivery system is capable of transporting the drug through skin into the blood circulation at fixed rate. Transdermal route gives an alternative to oral and i.v. delivery. ADVANTAGES : Transdermal delivery avoids the stomach environment where the drug can be degraded. Avoids the first pass effect . Improves bioavailability . Introduction 4 Absorption through skin : Absorption through skin 5 Drug delivery routes across human skin : Drug delivery routes across human skin Moeity passes through both keratinocytes and lipids.( ...

Microspheres Development of Floating Microspheres Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. Hollow microspheres are in strict sense, spherical empty particles without core. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Solid biodegradable microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for controlled release of drugs. Gastro-retentive floating microspheres are low-density systems that have sufficient buoyancy to float over gastric contents and remain in stomach for prolonged period. As the system floats over gastric contents, the drug is released slowly at desired rate resulting in increased gastric retention with reduced fluctuations in plasma drug concentration. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and ...

“The Role of Pharmacist in Health-Care System” Pharmacy play a vital role in health care system through the medicine and information they provide. Pharmacy is a profession that is expanding in new direction to meet the health care needs. One can see movement amongst pharmacist beyond compounding and dispensing of medicines, toward a more professional advisory and primary health care role. Health is a word very know but it carries a lot of complication and troubles. Health is a state of complete of physical, mental and social well-being and not merely absence of any illness. Health care system depends upon a health care team is group of community who contribute to a common health goal and common objectives determined by community needs. It is has been observed that from last few decades, the role of pharmacist has completely changed in the medication department. In older times, dispensing of drug was the main function assigned to pharmacist. With emergence of clinical phar...

Ø   Iontophoresis is a method of transferring substances across the skin by applying an electrical potential difference. Ø   It promotes the transfer of charged ionic drugs and possibly high molecular weight substances such as peptides. Ø   Electric current is applied through two electrodes, placed in the patient’s skin. The first, or donor, electrode (cathode) delivers the negatively charged therapeutic agent (e.g., an organic acid), where as the second or receptor, electrode (anode) serves to close the circuit. Ø   This setup is named cathodal iontophoresis.For positively charged drugs (e.g., amines or peptides),the cell arrangement is reversed called anodal iontophoresis. The silver (anode) and silver chloride(cathode) electrode system utilized in both types of iontophoresis.      

Microneedles (MNs) are small micron-sized needles which whenapplied on the skin breaches the SC to create microchannels throughthe skin thereby assisting drug delivery. Drug can be deliveredby variousmodes using these techniques. These modes are: (a) piercingan array of solidmicroneedles into the skin followed by application of adrug patch at the treated site (b) coating drug ontomicroneedlesand inserting them into the skin for subsequent dissolution of the coateddrug within the skin (c) encapsulating drug within biodegradable, polymericmicroneedles followed by insertion into the skin for controlleddrug release and   (d) injecting drug through hollow microneedles. The microchannels thus created help topically applied drugmolecules to by pass the SC which is the major rate limiting barrier for transdermal permeation.Moreovermicroneedles areminimally invasiveand painless as they do not penetrate up to the papillary dermis wherenerve endings are situated. In vivo ...